Is ALS Hereditary? My Mom died of this disease.?
About 5 to 10 percent of all ALS cases are inherited. The familial form of ALS usually results from a pattern of inheritance that requires only one parent to carry the gene responsible for the disease.
Mom and I have celiac disease. My boyfriend's dad (also celiac) came over to our house yesterday afternoon and gave my dad homemade bread...?
... that his wife and daughter made. He is the only celiac in the family and insists that none of the kids have it (though I suspect my boyfriend might have some issues with gluten as he has some celiac-like symptoms and doesn't look real healthy). They bake with flour at home, unlike us. My boyfriend's dad told me later on that he really believes that my dad is missing out due to mom's and my gluten free diet and it's a bit unfair for him. My dad was not impressed by this father's actions and insisted that Mom and I are not being unfair to him by keeping the house mostly gluten free. He thought this man's actions and what he said about mum and I depriving dad should make me assess more carefully whether or not my boyfriend is a keeper. What are your thoughts. I like my BF very much but it seems that his dad has got some issues...
Do identical twins usually get the same diseases b/c they have the same DNA?
Not necessarily. If you're talking about genetic disorders, then both would be candidates for the same thing to develop. But there could also be environmental triggers for these illnesses, that wouldn't necessarily be the same for both twins. And the same is true regarding exposure to bacteria and viruses. I can tell you from personal experience that my husband is an identical twin, yet his brother had severe childhood asthma and my husband never did.
If my parents are both heterozygous for a disease my sister has, what are the odds of me and my girlfriend having an affected baby (frequency in population =1/10 000)?
I am not sure how you derived that your chance of being a carrier was 2/3 - it does not make sense - if both your parents are heterozygous, then the chance that you are a carrier should be 1/2, with 1/4 being for non-carrier and the other 1/4 of being double-recessive. You can't rely on the remaining 3 scenarios and use that as a probability indicator (and increase your chance of being a carrier - which is more dependent on how your parents pass you the genes).Please note that the Hardy-Weinberg principle is intended for population level studies and not meant to predict individual events. It basically states that the frequencies of alleles remain stable across the generations (as long as no other external factors impacts upon the population). If you think that HW holds then the the odds of having an affected baby for any random couples (i.e. you and wife included) - would remain at 1/10,000.But if you were to simply focus on possibilities (and dropping the instance that both you and your wife are homozygous for the disease) then you can consider the following scenarios as equally likely:(1) Both you and your wife are homozygous for non-disease - which means the chance of your offspring getting the disease is 0(2) You are homozygous (non-D) and your wife is carrier - chance of offspring to get disease is still 0(3) You are carrier and your wife is homozygous (non-D) - chance of offspring to get disease is 0(4) Both you and wife are carrier - chance of off spring to get disease is 1/4If all 4 scenarios are equally likely then the chance of your offspring having the disease would be (0+0+0+1/4)/4 or 1/16.- well, that would be my simplistic estimation without invoking H-W - although I am intrigue at how Boris Bartlog derived his 1/50 figure for carriers
Can major mental diseases (personality disorders, psychotic disorders) be passed to next generations genetacly
Sure. Just like physical attributes that express by skipping a generation, mental attributes can also do the same. Genes affect your disposition for all kinds of health issues. Sometimes they skip a generation because the specific combination of genes wasn't expressed in the middle generation and instead lie dormant only to be passed on and re-expressed a generation later. Whether or not it expresses is really a matter of statistics. There is a chance it will get expressed and there is a chance it won't. Only rarely, when both parents have the same gene do the odds get stacked in favor of one chance or the other. Hope this helps
My kids’ dad is schizophrenic. Will my kids inherit schizophrenia?
Scientifically, it’s about a 23% chance to inherit if one parent has schizophrenia. Normally, it’s about a 4% chance if it runs in your family, but being the parent skews those odds.This is not a death sentence or the end of things, though. Often this means, because there is more awareness and preparedness of the potential of the illness, the child has a better outcome. The earlier the illness is caught, diagnosed, and treated, the more they will be responsive to medication and other treatment. You will, hopefully, have more education on your side about the illness and likely more compassion for those with it, all which contribute to a child who knows they can rely on their parent in times of need and crisis.My parents were woefully under-equipped for when I inherited it, and that caused a myriad of issues for me as it took a stronger hold upon me. A teenage girl I met was diagnosed at the age of 16 or 17, and because her family took her seriously and sought help immediately, she’s able to stay in school, responds well to medication, and is fairly stable. The thing that held her back the most is all the stories of those with the illness falling in and out of psychiatric wards, having endless problems with school, no stable employment, and being subject to endless stigmatization.Give your child hope, support, understanding, patience, and love. If they get the illness, they will have a strong support in their life and will be better off for it. If they don’t get the illness, they’ll still have all those things, and still be better off for it.Edit: I noticed several spelling and grammar mistakes, which is the trouble with doing these answers on my phone.
Do siblings who share the same set of parents each have the same distribution of parental DNA? Can one sibling have more of one parent's DNA or would the parental DNA distribution be equal?
First question: No, they do not.Reason: Recombination. Before an egg precursor cell splits a full set of paired DNA (diploid) into two egg cells with one set of DNA (haploid), the complementary DNA are somewhat randomly cut up and chunks swapped between them.Since this happens separately for each cell before it splits, each egg has a different mix of DNA in the chromosomes.The same thing happens when sperm are created in the male.So your mother got one set of DNA from her mother, and the other from her father. But when the egg is split into a haploid cell, any given chromosome consists of a mix of DNA from the chromosomes she received from her mother and her father. So you cannot say that, say, a chromosome that you received from your mother, came from your grandmother. Instead, it will be a mix of DNA from both your grandmother and your grandfather, due to recombination.The only chromosome for which this is not true are the X andY from the father, in which case a couple's daughters share an X from the father, and the sons share the Y from the father. No other chromosomes are untouched by recombination.Second question: It depends. Number of chromosomes, or total amount of DNA?Because each egg cell has 23 chromosomes, and each sperm cell has 23 chromosomes, each sibling will have an equal number of chromosomes from each parent. However, the Y chromosome is substantially smaller than the X chromosome, so technically girls have more DNA from their father than boys do.There are the somewhat rare cases of a boy inheriting two Y chromosomes from the father. Other mutations/mistakes involving multiple chromosomes don't seem to survive to birth.Thank you, Dan Theman, for correcting something I’d said about XYY. Despite what I’d been told long ago and the “popular wisdom”, there does not seem to be any particular correlation between XYY syndrome and any particular difficulties in behavior, intelligence, learning, or aggressive behavior.XYY syndrome - Wikipedia
Why do I keep having negative thoughts of my dad dying?
Considering your tragic loss your thoughts are understandable. I don't think you can control your thoughts but you can try to respond sensibly to them and keep telling yourself your father is safe and will be with you for a long time. You also have to develop an independent attitude so you know you will be able to take care of yourself no matter what. My mother passed away when I was 16 and worried about my father doing the same. There was a history of heart disease in his family. I was like you in my thoughts. My father did pass away at the age of 89 and not of heart disease, The years i spent worrying did nothing and were a waste of time.
Can two deaf parents have hearing children?
Yes, MOST deaf couples have hearing children. The majority of deaf parents are not deaf for genetic reasons, so there is no reason the children would be born deaf. So, for an example, my parents were both born Hearing, but when each was three years old, they contracted an illness that left them profoundly deaf. They grew up, met and married eachother, and had five Hearing children. next door to us was a couple with a different story. The husband was Hearing, the wife was deaf with a family history of genetic deafness. Of their five children, three were Hearing and two were Deaf. Their Hearing children went on to have all Hearing children. One Deaf child had no children that I know of, and the other Deaf child grew up to have two children, one Hearing, one Deaf.
If a mother and a father both have negative blood groups, will the second or first baby be affected or not?
If both parents have Rh- blood (whether it’s the same type: ex. B-/B-, or different type: ex. AB-/A-) the issues that come into play when the father has Rh+ blood and the mother has Rh- blood will not be an issue.If a father has Rh+ and the mother has Rh- , typically from the second child on there can be problems if the Rhogam injection was not given during the first pregnancy to prevent antibodies developing during the exposure to the babies blood during delivery, which the body will recognize as foreign, as its not compatible with the mothers blood type.Hope that’s helpful.