What would cause an initially hypercellular bone marrow to become hypocellular?
You may already know this about hyper cellular bone marrow. I didn't, so I'm including it here. What is hypercellular bone marrow?.Here is a different article about hypo cellular bone marrow and how to differentiate the causes. Differential Diagnosis and Bone Marrow Evaluation of New-Onset Pancytopenia. Good luck and may the higher power of your choice smile on you.
What is hypercellular with over cellularity of 85-90%?
In one line Hypercellularity means Hyperplasia (Increases in cell no. at particular organ or part)Hypercellular part or organ in human body means no. of cells at that part/organ is more than normal.This terminology is basically used for Bone marrow. (Hyperplasia of bone marrow)Generally cellularity fall in three categories,Hypercellular (More than 70%)Normocellular (In between 30%-70%)Hypocellular (Less than 30%)
Does the bone marrow a donor regrow after a donation?
A bone marrow is a soft tissue in the bones of the person involved in the function of producing of all kind of blood cells in the body. In order to live a healthy life, a person requires healthy bone marrow and blood cells. There are several diseases in bone marrow which can damage it prevents bone marrow from turning stem cells into essential cells.Yes, bone marrow regenerates after the donation. Bone marrow is present in most of the long bones in our body and it always regenerates. Donating bone marrow is like giving blood. The cells from your body will regenerate. It can take three weeks or more after a transfusion for the bone marrow cells to settle in and regenerate enough new cells to protect the body.Also, Visit here for bone marrow transplantation info:- Bone marrow transplant centers in India
Why is dry tap found during bone marrow aspiration in cases of leukaemia, multiple myeloma etc?
From Page on WwwFrom Dry tap bone marrow aspiration: Clinical significanceFailure to obtain bone marrow on attempted marrow aspiration, “dry tap”, has commonly been ascribed to faulty technique. All reports of simultaneous marrow aspirations and biopsies performed at the University of Virginia between January 1, 1983, and July 1, 1989, were reviewed to determine the frequency of dry taps, the diagnoses and pathologic findings in these cases, and the associated laboratory findings. Among 2,235 simultaneous bone marrow aspirations and biopsies, 87 were dry taps (3.9%). Of these 87 dry taps, only six (6.9%) showed normal marrow biopsies, whereas the majority showed significant marrow pathology, usually associated with fibrosis, or hypercellularity, or both. These conditions most likely account for the inability to aspirate marrow. The most frequent diagnoses were metastatic carcinoma (17.2%), chronic myelogenous leukemia (14.9%), idiopathic myelofibrosis (13.8%), and hairy cell leukemia (10.3%). So caused by too compacted cellular bone marrow?
Need help with a case study in human patho please?
A 60-year-old man presents with headaches and pruritis. Physical examination reveals splenomegaly but no lymphadenopathy. A CBC demonstrates elevated hemoglobin of 19.5 g/dL, WBC of 12,800/µL, and platelets of 550,000/µL. The bone marrow displays hypercellularity of all lineages and depletion of marrow iron stores. Which of the following is the most likely diagnosis? 1) acute myelogenous leukemia 2) essential thrombocythemia 3) idiopathic myelofibrosis 4) occult infection 5) polycythemia vera And with this question.... what will the patient be at an increased risk of developing 1) cerebral aneurysm 2) cerebrovascular accident 3) cholelithiasis 4) osteogenic sarcoma 5) paynaud phenomenom
Is blood cancer hereditary?
Hey, A hereditary cancer develops as a result of a gene mutation that is passed down from a parent to a child. It is important to remember that cancer is not inherited, only the gene that increases the risk of developing it.Cancer involves mutations, or changes, in genes. In most people affected by cancer, these genetic changes happen after birth later in life. In Hereditary Cancer, the cancer is caused by a genetic mutation that the person was born with. Some cancers, such as breast, ovary and colon tend to be hereditary, but that doesn't mean that you will develop a cancer in one of these areas if you have an immediate family member that has experienced the disease. Not all genetic mutations will develop into cancer, however, the mutation will increase the chance that the person will have a higher risk of developing cancer. Only 10% of all breast cancer cases are thought to be hereditary. Some of the factors that increase the occurrence of hereditary breast cancer are breast cancer before age 45, male breast cancer, cancer in both breasts and many cases of breast and/or ovarian cancer on one side of the family. If you have two relatives from the same side of your family with breast cancer, your risk of getting the disease can be increased. However it does not mean that you will definitely get breast cancer. You also must keep in mind that the risk for hereditary cancer can be passed on from your mother or your father. You must look at both sides of the family. The two hereditary mutations that are looked at for breast cancer are BRCA1 and BRCA2. The test for these two genetic factors are done by taking a blood sample. Both of these BRCA mutations (BReast CAncer 1 and 2) are associated with breast and ovarian cancers. Blood cancer is not yet been proved as hereditary... However, if you need any additional help online from people who have fought or are fighting cancer kindly visit the web page or Facebook page of an NGO named Yoddhas. They provide online support for Cancer Patients.
Can anyone talk to me about Polycythemia vera?
Polycythemia vera is a rare, chronic disorder where the bone marrow overproduces blood cells. It increases all blood cells: red, white and platelets. The cause is unknown. Symptoms include headaches, weakness, dizziness, and/or a ringing in the ears. Some people also have itching. The spleen and liver can be enlarged. People can also have high blood pressure and develop blood clots.
How are blast cells counted in blood cell count?
This is part of the work I do daily. No, analyzers cannot distinguish myeloid from lymphoid blasts because blasts of both lineages have similar characteristics (large, high N:C ratio, few or no granules). It requires a manual differential to distinguish is them from one another, and even then it can be tricky. Many times myeloid blasts do not contain Auer rods so it's impossible to make that assumption without other indicators such as promyelocytes present.Even in the 21st century, most analyzers still confuse dense, mononucleated (such as reactive lymphocytes and lymphoma cells) cells for blasts, which is why the microscopist is very important.The good thing here is that modern analyzers will flag these samples as being abnormal, which reflexes to manual differential. So, don't fear that blast will go undetected.
Aplastic Anemia?
I've not had aplastic anemia, but have had experience with needing a second opinion. How old is your daughter? Depending on how old she is; if she is a minor, you are her legal guardian and live in USA the doctor cannot legally refuse to release her records. If she is old enough to take care of her own health problems talk to your daughter and see if she will get her records and go elsewhere for a second opinion. There isn't anything you can do if she refuses and is independent of you. Check with a lawyer if there is a question of legality; because of the new Privacy Act that was passed a few years ago there is a lot of intricacies to getting medical info now. Most doctors don't have a problem with somebody getting a second opinion. If he is really doing it to stop you from getting a second opinion, that is a definite red flag. You can always take your daughter to a second doctor without her records. They like old records, but they aren't absolutely necessary. They would have to redo tests that she has already had done though. That might be a problem depending on what type of insurance you have.
What happens if a leukaemic person has AIDS?
Scientists have proven that HIV induced suicide drived most CD4 T cell depletion, rather than direct killing of viral replication.However, in cancerous cells, suicide pathways are generally inactivated because it's detrimental to tumor proliferation. Since HIV is inefficient at killing directly. We can expect that the these tumor cells would be a nice factory of HIV. So the patient may display extremely high viral load.And what's more, since normal T cells are much more likely be killed by HIV, we can expect that the poor patient may lost his T cell quickly, i.e. progress to AIDS.