How were you able to lower your weed tolerance?
By not smoking weed.Receptors "downgrade" and you need more and more to get the same release of dopamine, serotonin etc.I'm on month two of a mega clean out.I started off just planning a week or so.But, I did not feel any real craving to smoke, as I had moved to a place where my ATP output and therefore overall brain neurochemical output is just as "high" without my Rx and so I have just forgone buying any.I have my eye on a 2.99 tiny pipe as I only micro dose it anyway.Mitochondrial function dictates dosages needed.Oh, and I typically only use indica strains…love my serotonin.Forgoe the munchies and get high on less indica by pre-loading on some chocolate 15 min before you smoke.Serotonin is predominantly produced in the gut by direct carbohydrate breakdown.We no longer store serotonin in the pineal…it's just a lump of rock now.E-GO 2018
Would taking a 1 week break from Zopiclone reduce tolerance and increase effectiveness?
Yes. Albeit the tolerance will likely build back to it's current state more quickly than it initially did. IE: You take a 2 week break,.. then consume Zopiclone, it is more effective than it was today/last night - but within that week of regularly taking it , it wouldn't be uncommon to become as ineffective as it currently is. So, short answer is: Yes. A break will reduce tolerance. The tolerance is built due to the brains adaption to the GABA receptors being targeted by the "Z" drug. Just about every drug known to man will become less effective over time.. due to our own bodies adaptation. These types of drugs are most effective when taken infrequently for infrequent insomnia. When taking on a nightly, or several days per week basis -- they quickly become less effective, to eventually ineffective. Take care,
Stimulant tolerance from caffeine?
That would be the case if caffeine and amphetamine-based stimulants were in the same drug class. Caffeine belongs to the xanthine class, while amphetamine belongs to the phenethylamine class and methylphenidate is a piperadine derivative. Now, although there is cross-tolerance between amphetamine and methylphenidate/cocaine, this is mainly because they both possess similar pharmacodynamics. Amphetamine is a dopamine/norepinephrine releasing agent and reuptake inhibitor, while methylphenidate/cocaine only possess reuptake inhibitory action. Caffeine, on the other hand, acts in a completely different way. Caffeine is an adenosine antagonist and acetylcholinesterase inhibitor. Antagonizing these chemicals indirectly elicits stimulation by allowing excitatory neurotransmitters to build up instead of being broken down and recycled. However, this does not adversely affect the stimulatory chemoreceptors themselves because there is no direct occupation by the caffeine molecules. Also, the amount of neurotransmitter build-up is not nearly as much as that which occurs from amphetamine exposure. The ironic thing is that amphetamine/methylphenidate actually potentiate the effects of caffeine to about 5 times the original potency. This is why amphetamine users should limit the amount of caffeine they ingest.
Which is better, high tolerance or low tolerance of a resistor?
Low tolerance (1%) means the resistor value will be within a narrower limit. That might cost you slightly higher cost.Low tolerance is necessary when you are designing electronic circuits used to generate precise outputs such as charger for Lithium battery or bridge arms for weigh bridge sensor.If you are building circuits where transistors are used in saturation or cutoff then a wide range of resistor values can be chosen and hence higher tolerance (5% or 10%) and cheaper resistors can be used.
How can I gradually stop consuming 7.5mg of zopiclone?
Since you are talking about dependence and feeling sick, and describing a pretty severe tolerance, than you are well past the stage of taking zopiclone to fall asleep. You are taking this drug to avoid withdrawal symptoms, and trying to get off this without the proper support can be very dangerous, even life-threatening. Trying to avoid withdrawal symptoms with flowers is useless at best, and life-threatening at worst. Zopiclone, even though it is not a benzodiazepine, has been called a benzodiazepine in disguise. It has many benzodiazepine-like properties, even though it was originally marketed as a safer, less addicting alternative to benzodiazepines such as Ambien and Xanax. However, just like heroin was initially promoted as a cure for morphine addiction, in this case too the cure is worse than the disease. Addiction to zopiclone is both easier and more dangerous than addiction to benzodiazepines. The treatment for any addiction is to substitute a similar drug that is easier to withdraw from. In your case, it must be a benzodiazepine. One that is commonly used in this situation is one that has not been commonly used for the reason you were taking zopiclone for in years, and that is valium. Valium has the advantage that it is easier to withdraw from, and it has a half life of several days. What you will do is gradually transfer from zopiclone to valium, and then gradually withdraw from valium. As I mentioned above, withdrawal from this drug can be extremely dangerous, and substituting with anything else but another benzodiazepine is also dangerous and life-threatening. With the clinical presentation you provide, this definitely needs to be done under the direct supervision of a doctor, one that is trained in addiction management.Addendum: I mentioned in my answer that this medication can cause tolerance and severe tolerance. The usual dose is 7.5 mg at bedtime, so the fact that you need to take 4 means you are taking quadruple the usual dose, indicating tolerance, and the 2 during the day to feel normal, i.e. to avoid withdrawal symptoms, indicates addiction.Good luck to you. Everything that happens to you in life is part of a lifelong education.
How many 7.5 Zopiclone sleeping tablets would it take to kill you?
Omg have i done research on this…. They wont!! Full stop. It takes a whole cocktail of medications taken in the correct dosages in the correct order to kill you. Its a foolproof mixture IF you arent discovered while the mixture takes effect. It takes 24 to 48 hours of excruciating pain which ur too doped up to do anything about. If u chicken out or get found u stand the chance of lying in hospital suffering the slow process of organ failure. Even if u survive that your quality of life will be 10 times worse than before.Bottom line….its not worth it. If you can take the time and effort to research ways to ofd yourself, you can take the time and effort to rather ask for help with your problems. My answer is blunt but only because ive been there, lying on the floor vomitting on myself unable to move my muscles. Please PLEASE put this crazy question out of your mind.
Can ZOPICLONE cause breathing problems?
Yes it can cause breathing problems. All prescription tranquillisers and sleeping pills can cause depression of respiratory function. I will warn you that zopiclone can cause withdrawal symptoms both mental and physical if it is stopped rapidly. Your mother may need to cut the dose down by a quarter or less every 4 - 6 weeks if she has been on this drug for more than a few months. Here is a group which offers advice on stopping drugs like zopiclone http://www.non-benzodiazepines.org.uk